OBJECTIVE: The aim of the study was to evaluate time to virological suppression in a cohort of individuals who started highly active antiretroviral therapy (HAART), and to explore the factors associated with suppression. METHODS: Eligible participants were HIV-positive individuals from a multi-site Canadian cohort of antiretroviral-naïve patients initiating HAART on or after 1 January 2000.Résumé en Langage Simple
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The Canadian Observational Cohort (CANOC) collaboration is Canada’s first interprovincial collaborative cohort of HIV-positive individuals on ART. This collaboration of nine cohorts from BC, Ontario and Quebec gives researchers the opportunity to conduct large and detailed analyses of HIV treatment outcomes that would not be possible within individual cohorts and to assess variations in patterns
A CD4+ cell count <200 cells per cubic millimeter at 2 years after initiation of combination antiretroviral therapy is associated with increased mortality in HIV-infected individuals with viral suppression
OBJECTIVE: To determine the long-term impact of immunologic discordance (viral load METHODS: Our analysis included antiretroviral-naive individuals from a population-based Canadian Observational Cohort that initiated cART after January 1, 2000, and achieved virologic suppression. Multivariable Cox proportional hazards regression was used to examine the association between 1-year and 2-year immunologic discordance and time to deathRésumé en Langage Simple
Regional differences in rates of HIV-1 viral load monitoring in Canada: Insights and implications for antiretroviral care in high income countries
BACKGROUND: Viral load (VL) monitoring is an essential component of the care of HIV positive individuals. Rates of VL monitoring have been shown to vary by HIV risk factor and clinical characteristics. The objective of this study was to determine whether there are differences among regions in Canada in the rates of VL testing ofRésumé en Langage Simple